Page last updated: May 2026

ASCO 2026

ASCO-2026-Gambardella-Poster
Analysis of delta-like ligand 3 (DLL3) expression levels and characteristics of patients with advanced extrapulmonary neuroendocrine carcinomas (epNECs) from an ongoing Phase I trial
Author(s): Gambardella et al.
NEC/epNEC DLL3/CD3 TcE Poster
ASCO-2026-Peters-Poster.
DAREON®-8: updated efficacy and safety from a Phase I dose-escalation/expansion trial of first-line obrixtamig plus chemotherapy and atezolizumab in extensive-stage small cell lung carcinoma
Author(s): Peters et al.
SCLC DLL3/CD3 TcE Poster

ELCC 2026

ELCC-2026-Mazieres-Presentation
A Phase I dose escalation trial of obrixtamig + ezabenlimab in patients with small cell lung cancer (SCLC) or other neuroendocrine carcinomas (NECs) expressing DLL3
Author(s): Mazières et al.
SCLC + NEC/epNEC DLL3/CD3 TcE Presentation

ENETS 2026

ENETS-2026-Capdevila-Presentation
DAREON®-7: Phase I open-label dose-escalation/expansion study of first-line obrixtamig (BI 764532) plus platinum-doublet chemotherapy in patients with DLL3-positive neuroendocrine carcinomas
Author(s): Capdevila et al.
NEC/epNEC + LCNEC-L DLL3/CD3 TcE Presentation

ASCO GU 2026

ASCO-GU-2026-Navarro-Gorro-Poster
Efficacy and safety of the DLL3/CD3 T-cell engager obrixtamig in patients with extrapulmonary neuroendocrine carcinomas of genitourinary origin with high or low DLL3 expression: results from an ongoing Phase I trial
Author(s): Navarro-Gorro et al.
NEC/epNEC DLL3/CD3 TcE Poster

NANETS 2025

NANETS-2025-Chauhan-Poster
DAREON®-7: Phase I open-label dose-escalation/-expansion study of first-line obrixtamig (BI 764532) plus platinum-doublet chemotherapy in patients with DLL3-positive neuroendocrine carcinomas
Author(s): Chauhan et al.
NEC/epNEC, LCNEC-L DLL3/CD3 TcE Poster

ESMO 2025

ESMO 2025 Kim Poster
Ezabenlimab (BI 754091) and induction mDCF (modified docetaxel, cisplatin, and 5-fluorouracil) followed by adaptive chemoradiotherapy in patients with stage III squamous cell anal carcinoma: final results of the Phase II INTERACT-ION study
Author(s): Kim et al.
SCCA PD-1 inhibitor Poster
ESMO 2025 Laban Poster
An open-label, Phase Ib trial to assess the safety and efficacy of SIRPα monoclonal antibody BI 770371 in combination with pembrolizumab with or without cetuximab compared with pembrolizumab monotherapy for the first-line treatment of patients with head and neck squamous cell carcinoma (NCT06806852)
Author(s): Laban et al.
HNSCC SIRPα antagonist Poster
Phase Ia results for systemic STING agonist BI 1703880 plus ezabenlimab in patients with advanced solid tumors: progress to date
Phase Ia results for systemic STING agonist BI 1703880 plus ezabenlimab in patients with advanced solid tumors: progress to date
Author(s): Parkes et al.
Solid tumors STING agonist, PD-1 inhibitor Presentation
ESMO 2025 Pavel Poster
Obrixtamig (BI 764532) in patients with relapsed/refractory DLL3-high expressing extrapulmonary neuroendocrine carcinoma: trial in progress of the dose expansion part of the Phase II DAREON®-5 trial
Author(s): Pavel et al.
NEC/epNEC DLL3/CD3 TcE Poster
DAREON®-8: A Phase I trial of first-line obrixtamig plus chemotherapy and atezolizumab in extensive-stage small cell lung carcinoma (ES-SCLC)
DAREON®-8: A Phase I trial of first-line obrixtamig plus chemotherapy and atezolizumab in extensive-stage small cell lung carcinoma (ES-SCLC)
Author(s): Peters et al.
SCLC DLL3/CD3 TcE Presentation
ESMO-2025-Wermke-Poster
DAREON®-9, a Phase Ib open-label dose escalation and dose confirmation study of obrixtamig (BI 764532) plus topotecan in patients with advanced small cell lung cancer: updated results
Author(s): Wermke et al.
SCLC DLL3/CD3 TcE Poster

ASCO 2025

An open-label, phase I trial of the SIRPα monoclonal antibody, BI 770371, alone and in combination with the PD-1 inhibitor ezabenlimab in patients with advanced solid tumors
An open-label, Phase I trial of the SIRPα monoclonal antibody, BI 770371, alone and in combination with the PD-1 inhibitor ezabenlimab in patients with advanced solid tumors
Author(s): Wang et al.
Solid tumors SIRPα antagonist, PD-1 inhibitor Presentation
An open-label, phase Ib trial of the SIRPα inhibitor BI 765063 in combination with the PD-1 inhibitor ezabenlimab and cetuximab in patients with head and neck squamous cell carcinoma
An open-label, Phase Ib trial of the SIRPα inhibitor BI 765063 in combination with the PD-1 inhibitor ezabenlimab and cetuximab in patients with head and neck squamous cell carcinoma
Author(s): Rojas et al.
HNSCC SIRPα antagonist, PD-1 inhibitor Presentation
ASCO 2025
To view all ASCO 2025 publications, please see the All Congress Publications section

AACR 2025

An open-label, Phase Ib, dose-expansion study to assess the efficacy of CD137 FAP agonist BI 765179 plus pembrolizumab as a first-line treatment in metastatic or incurable, recurrent, programmed cell death ligand-1 (PD-L1)-positive, head and neck squamous cell carcinoma (HNSCC)
An open-label, Phase Ib, dose-expansion study to assess the efficacy of CD137 FAP agonist BI 765179 plus pembrolizumab as a first-line treatment in metastatic or incurable, recurrent, programmed cell death ligand-1 (PD-L1)-positive, head and neck squamous cell carcinoma (HNSCC)
Author(s): Shroff et al.
HNSCC CD137xFAP bsAb Poster
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View congress publications and pipeline information

Beamion™ LUNG-2 

Learn about the Beamion™ LUNG-2 Trial.

Obrixtamig (DLL3/CD3)

Learn about our Phase III DLL3/CD3 T-cell engager (obrixtamig) trials.

Vault id: SC-CRP-16532